Description

2-(Acetylamino)-2-Deoxy-1-Thio-α-D-Glucopyranose is a specialized thioglycoside derivative of N-acetylglucosamine, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key precursor in the development of glycosidase inhibitors and carbohydrate-based pharmaceuticals, where its thio-sugar scaffold offers unique reactivity and metabolic stability. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing treatments targeting metabolic disorders and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel glycosidase inhibitors and antiviral/antimicrobial agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate carbohydrate metabolism pathways.
• Glycobiology & Glycochemistry: Serves as a versatile building block for constructing complex oligosaccharides, glycoconjugates, and glycomimetics.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting carbohydrate-processing enzymes.
• Chemical Biology Probes: Utilized in the development of activity-based probes (ABPs) for labeling and studying glycosidases in biological systems.

Basic Information

Product Name	2-(Acetylamino)-2-Deoxy-1-Thio-α-D-Glucopyranose
CAS No.	781581-10-0
Molecular Formula	C8H15NO5S
Molecular Weight	237.27 g/mol
Synonyms	1-Thio-α-D-N-acetylglucosamine; 2-Acetamido-2-deoxy-1-thio-α-D-glucopyranose; 1-Thio-N-acetyl-α-D-glucosamine; α-D-1-Thio-GlcNAc; N-Acetyl-1-thio-α-D-glucosamine; 2-Acetamido-1,2-dideoxy-1-thio-α-D-glucopyranose; 2-(Acetylamino)-2-deoxy-1-thio-α-D-glucopyranose; 1-Thio-α-D-GlcNAc
EINECS	Contact for details

Quality Control

Our 2-(Acetylamino)-2-Deoxy-1-Thio-α-D-Glucopyranose is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere for long-term stability. This material is hygroscopic and should be handled in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.