Description

3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide and fluorinated tetrahydroisoquinoline structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those with sulfonamide pharmacophores.
• Drug Discovery & Medicinal Chemistry: Used in research libraries and for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Synthesis: A key raw material in the production route for potential APIs targeting neurological and psychiatric conditions.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing for clinical trial material supply.
• Biochemical Research: May be utilized as a tool compound or inhibitor in enzymatic and receptor binding assays.

Basic Information

Product Name	3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide
CAS No.	780820-78-2
Molecular Formula	C₁₀H₁₁FN₂O₃S
Molecular Weight	258.27 g/mol
Synonyms	7-Sulfamoyl-3-(fluoromethyl)-3,4-dihydro-1H-isoquinolin-1-one; 3-(Fluoromethyl)-1,2,3,4-tetrahydro-1-oxo-7-isoquinolinesulfonamide; 3-Fluoromethyl-7-sulfamoyl-3,4-dihydroisoquinolin-1(2H)-one; 780820-78-2; 3-(Fluoromethyl)-7-sulfamoyl-3,4-dihydro-1H-isoquinolin-1-one; 3-(Fluoromethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
EINECS	Contact for details

Quality Control

Our 3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.