Description

3-(Fluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents targeting complex diseases. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation drug candidates, particularly in the fields of neurology and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Library Synthesis: Serves as a versatile scaffold for generating diverse compound libraries in high-throughput screening.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of new chemical entities.
• Biochemical Probe Development: Utilized in the creation of tool compounds for investigating specific biological pathways and enzyme functions.

Basic Information

Product Name	3-(Fluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide Hydrochloride
CAS No.	780820-69-1
Molecular Formula	C10H14ClFN2O2S
Molecular Weight	280.75 g/mol
Synonyms	7-Sulfamoyl-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 3-(Fluoromethyl)-7-sulfamoyl-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-3-(fluoromethyl)-7-isoquinolinesulfonamide hydrochloride; 780820-69-1; 3-Fluoromethyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide HCl; 3-Fluoromethyl-7-sulfamoyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Fluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.