Description

1-Isoquinolinecarboxylicacid,4-Amino-1,2,3,4-Tetrahydro-3-Oxo-,trans-(9Ci) is a specialized heterocyclic building block featuring a fused isoquinoline core with amino and carboxylic acid functionalities. This compound matters as a key chiral intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and cardiovascular diseases.
• Organic Synthesis Building Block: Used in the construction of complex polycyclic frameworks and natural product analogs due to its fused isoquinoline structure.
• Ligand and Catalyst Precursor: The amino and carboxylic acid groups allow for chelation, making it a precursor for specialized ligands in asymmetric catalysis.
• Agrochemical Research: Employed in the discovery and synthesis of new generation pesticides and herbicides with specific biological activity.
• Academic and R&D Laboratories: Utilized in methodological studies and as a reference standard in chemical research focused on heterocyclic chemistry.

Basic Information

Product Name	1-Isoquinolinecarboxylicacid,4-Amino-1,2,3,4-Tetrahydro-3-Oxo-,trans-(9Ci)
CAS No.	780726-56-9
Molecular Formula	C10H10N2O3
Molecular Weight	206.20 g/mol
Synonyms	trans-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid; (3R,4S)-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid; 4-Amino-3-oxo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1-Carboxy-4-amino-1,2,3,4-tetrahydro-3-oxoisoquinoline; ATOIQC; 780726-56-9; (3R,4S)-4-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dicarboxylic acid 1-ethyl ester (related ester); 4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid, trans-
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Quality Control

Our 1-Isoquinolinecarboxylicacid,4-Amino-1,2,3,4-Tetrahydro-3-Oxo-,trans-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.