Description

Hs-Peg10-Tbu CAS NO 778596-28-4 is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyl (tBu) protecting group. This compound is engineered to serve as a critical building block in advanced bioconjugation and pharmaceutical formulation, enabling precise and stable linker chemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require controlled functionalization for drug delivery systems, diagnostic reagents, and polymer therapeutics.

Application

• Bioconjugation Linker: Used for the controlled attachment of drugs, proteins, or targeting ligands in antibody-drug conjugates (ADCs) and other therapeutic constructs.
• Pharmaceutical Formulation: Acts as a solubilizing agent and a stealth component in liposomal and nanoparticle-based drug delivery platforms to enhance circulation time.
• Polymer Chemistry: Serves as a key monomer or macroinitiator for synthesizing well-defined, functionalized PEG-based block copolymers and hydrogels.
• Diagnostic Reagents: Utilized in the development of contrast agents and fluorescent probes for medical imaging and in vitro diagnostics.
• Surface Modification: Applied to functionalize nanoparticles, biosensors, and medical device surfaces to improve biocompatibility and reduce non-specific binding.
• Peptide/Protein Modification: Enables site-specific PEGylation to improve the pharmacokinetic properties and stability of therapeutic peptides and proteins.

Basic Information

Product Name	Hs-Peg10-Tbu
CAS No.	778596-28-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(tert-Butyl) 1'-(2,5-dioxopyrrolidin-1-yl) deca(ethylene glycol) ester; Heterobifunctional PEG10-tBu NHS ester; tert-Butyl-PEG10-NHS; NHS-PEG10-tButyl ester; HS-PEG10-tBu; PEG-based heterobifunctional crosslinker with tBu and NHS groups; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21,24,27,30-decaoxa-33-azapentatriacontan-35-oate, 33-(tert-butyl); tBu-PEG10-SCM
EINECS	Contact for details

Quality Control

Our Hs-Peg10-Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and functional group analysis, to ensure it meets the high standards required for pharmaceutical and biotech research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.