Description

4-(Trifluoromethyl)Thiophen-2-Amine is a high-purity, fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the versatile reactivity of the aminothiophene scaffold, enabling the development of novel compounds with enhanced properties. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group can improve metabolic stability and bioavailability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An essential compound for academic and industrial research exploring the effects of fluorine substitution on molecular properties and reactivity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	4-(Trifluoromethyl)Thiophen-2-Amine
CAS No.	777846-37-4
Molecular Formula	C5H4F3NS
Molecular Weight	167.15 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)thiophene; 4-(Trifluoromethyl)-2-thiophenamine; 2-Thiophenamine, 4-(trifluoromethyl)-; 4-Trifluoromethylthiophen-2-ylamine; 4-CF3-Thiophen-2-amine; 2-Amino-4-trifluoromethylthiophene; α,α,α-Trifluoro-2-amino-4-thiophenemethane
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Thiophen-2-Amine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure compliance with exacting purity standards and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.