Description

1-tert-Butoxycarbonylindole-5-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, particularly for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-couplings for synthesizing novel drug candidates, especially those containing indole scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular assembly is required.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Academic & Contract Research: A valuable reagent for methodology development and complex natural product synthesis in university and CRO laboratories.
• Scale-up Process Chemistry: Suitable for optimization and pilot-scale production of target molecules due to its stability and reactivity profile.

Basic Information

Product Name	1-tert-Butoxycarbonylindole-5-Boronic Acid, Pinacol Ester
CAS No.	777061-36-6
Molecular Formula	C19H26BNO4
Molecular Weight	343.23 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-N-Boc-indole-5-boronic acid pinacol ester; Indole-5-boronic acid pinacol ester, N-Boc protected; BOC-Indole-5-Bpin
EINECS	Contact for details

Quality Control

Every batch of 1-tert-Butoxycarbonylindole-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.