Description

cis-Montelukast CAS NO 774538-96-4 is a specific stereoisomer of the leukotriene receptor antagonist Montelukast, characterized by its cis-configuration. This compound is of significant interest in pharmaceutical research and development, particularly for investigating structure-activity relationships and as a key intermediate or reference standard. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs) and their related substances.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of Montelukast sodium and related drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthetic pathway for producing Montelukast and its stereoisomers.
• Biochemical Research: Employed in preclinical studies to explore the pharmacological profile, metabolism, and receptor binding affinity of different Montelukast stereoisomers.
• Impurity Profiling: Essential for identifying, quantifying, and monitoring the cis-isomer as a potential impurity in batches of the trans-Montelukast API to ensure compliance with ICH guidelines.
• Process Chemistry Development: Utilized by chemists to optimize synthetic routes, improve stereoselectivity, and scale up production processes for leukotriene modifier drugs.

Basic Information

Product Name	cis-Montelukast
CAS No.	774538-96-4
Molecular Formula	C35H35ClNO3S
Molecular Weight	585.18 g/mol
Synonyms	1-(((1(R)-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid, cis-isomer; Montelukast cis-isomer; (R)-Montelukast cis-isomer; cis-MK-0476; cis-Singulair impurity; Leukotriene D4 receptor antagonist cis-isomer; 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
EINECS	Contact for details

Quality Control

Our cis-Montelukast is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity, to ensure it meets high-purity standards suitable for research and development purposes. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and related substances is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% cis-isomer
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.