Description

4,7,8-Isoquinolinetriol,1,2,3,4-Tetrahydro-1,2-Dimethyl-,cis-(9Ci) is a specialized, high-purity synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its unique polyhydroxylated isoquinoline structure, which serves as a critical building block for the development of novel pharmacologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of complex heterocyclic compounds targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those with isoquinoline-based scaffolds for central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Reagent: Used in complex multi-step syntheses to introduce the polyhydroxylated tetrahydroisoquinoline moiety into larger molecular architectures.
• Biochemical Tool Compound: Potential use in developing probes for studying enzyme inhibition or receptor binding activities in biochemical assays.
• Academic Research: Employed in university and institutional labs for methodological development in heterocyclic chemistry and asymmetric synthesis.
• Fine Chemical Production: Intermediate in the custom manufacturing of high-value, low-volume specialty chemicals for advanced material science applications.

Basic Information

Product Name	4,7,8-Isoquinolinetriol,1,2,3,4-Tetrahydro-1,2-Dimethyl-,cis-(9Ci)
CAS No.	774139-35-4
Molecular Formula	C11H15NO3
Molecular Weight	209.24 g/mol
Synonyms	cis-1,2-Dimethyl-1,2,3,4-tetrahydro-4,7,8-isoquinolinetriol; 1,2,3,4-Tetrahydro-1,2-dimethyl-4,7,8-isoquinolinetriol, cis-; (1R,2S)-1,2-Dimethyl-1,2,3,4-tetrahydroisoquinoline-4,7,8-triol; 4,7,8-Trihydroxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline (cis isomer); 9CI-774139-35-4; cis-Tetrahydrodimethylisoquinolinetriol
EINECS	Contact for details

Quality Control

Our 4,7,8-Isoquinolinetriol,1,2,3,4-Tetrahydro-1,2-Dimethyl-,cis-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines for advanced intermediates, ensuring traceability and documentation suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.