Description

1H-Indole-3-Carboxylic Acid, 1-[(3,5-Difluorophenyl)Methyl]-Ethyl Ester is a high-purity, fluorinated indole derivative serving as a critical advanced intermediate in modern synthetic chemistry. This compound is valued for its unique molecular architecture, which combines an indole core with a difluorobenzyl moiety, enabling precise structural modifications in complex molecule synthesis. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the discovery and optimization of novel active pharmaceutical ingredients (APIs) and other biologically relevant compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorinated indole structure can contribute to enhanced biological activity and environmental stability.
• Material Science Precursor: Serves as a specialty monomer or precursor for advanced polymers and organic electronic materials requiring specific optoelectronic properties.
• Biochemical Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity fluorinated intermediates.

Basic Information

Product Name	1H-Indole-3-Carboxylic Acid, 1-[(3,5-Difluorophenyl)Methyl]-Ethyl Ester
CAS No.	773138-31-1
Molecular Formula	C18H15F2NO2
Molecular Weight	315.32 g/mol
Synonyms	Ethyl 1-[(3,5-difluorophenyl)methyl]-1H-indole-3-carboxylate; 1-[(3,5-Difluorobenzyl)]-1H-indole-3-carboxylic acid ethyl ester; 1-(3,5-Difluorobenzyl)indole-3-carboxylic Acid Ethyl Ester; 1H-Indole-3-carboxylic acid, 1-[(3,5-difluorophenyl)methyl]-, ethyl ester; 773138-31-1; UNII-8Q6K8Q3Q1F
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-3-Carboxylic Acid, 1-[(3,5-Difluorophenyl)Methyl]-Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.