Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Methyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid derivative and a key protected intermediate in modern synthetic chemistry. This compound matters for its role in facilitating complex coupling reactions, particularly in the synthesis of biologically active molecules. Pharmaceutical researchers and process chemists need this high-purity building block for developing new drug candidates, especially in areas like kinase inhibitor research and targeted therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted cancer therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds under mild conditions, essential for constructing complex heterocyclic scaffolds.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linker molecules and warhead components for targeted protein degradation platforms.
• Kinase Inhibitor Synthesis: A key precursor in the manufacturing of selective kinase inhibitors due to its indole and piperazine motifs.
• Bioconjugation and Labeling: Employed in the development of diagnostic agents and antibody-drug conjugates (ADCs) where stable boron-containing linkages are required.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-Up: Supplied under cGMP-like controls for use in pilot plant and commercial-scale manufacturing of clinical trial materials.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Methyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	771477-41-9
Molecular Formula	C24H36BN3O5
Molecular Weight	457.37 g/mol
Synonyms	tert-Butyl 2-borono-5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-1H-indole-1-carboxylate; 2-Borono-5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-2-borono-5-((4-Boc-piperazin-1-yl)methyl)indole; Boronic Acid Ester Intermediate 771477-41-9; PROTAC Linker Boronic Acid; (1-(tert-Butoxycarbonyl)-5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-1H-indol-2-yl)boronic acid pinacol ester derivative precursor.
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Methyl]-, 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, NMR) are provided to support your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.