Description

7-Fluoroindoline is a versatile fluorinated heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in the strategic incorporation of a fluorine atom into the indoline scaffold, enabling the fine-tuning of physicochemical and biological properties in target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the fluorine atom enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic materials, including liquid crystals and organic semiconductors.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies to investigate fluorine's effects on binding affinity and pharmacokinetics.
• Catalyst and Ligand Development: The indoline nitrogen can be functionalized to create novel chiral ligands for asymmetric catalysis.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of positron emission tomography (PET) tracers, given its fluorinated structure.

Basic Information

Item	Details
Product Name	7-Fluoroindoline
CAS No.	769966-04-3
Molecular Formula	C8H8FN
Molecular Weight	137.15 g/mol
Synonyms	7-Fluoro-2,3-dihydro-1H-indole; 1H-Indole, 7-fluoro-2,3-dihydro-; 2,3-Dihydro-7-fluoro-1H-indole; 7-Fluoroindoline; 7-Fluoro-2,3-dihydroindole; 769966-04-3; AI3-52722; SCHEMBL2180621
EINECS	Contact for details

Quality Control

Our 7-Fluoroindoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable and consistent material for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.