Description

(R)-2-Amino-1,1-difluoro-2-phenylethylphosphonic acid is a high-value, chiral organophosphorus compound featuring a unique difluoroethyl backbone. This molecule is critical for its role as a sophisticated building block in the synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in developing novel herbicides, pesticides, and plant growth regulators that leverage its phosphonic acid and fluorine motifs.
• Ligand & Catalyst Synthesis: Employed for constructing chiral phosphonate-based ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Biochemical Probe Development: Acts as a stable, fluorine-tagged mimic of phosphate esters for studying enzyme mechanisms and metabolic pathways.
• Advanced Material Precursor: Utilized in the synthesis of specialty polymers and flame retardants where phosphorus and fluorine functionalities are required.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.

Basic Information

Product Name	(R)-2-Amino-1,1-difluoro-2-phenylethylphosphonic Acid
CAS No.	769195-98-4
Molecular Formula	C8H10F2NO3P
Molecular Weight	237.14 g/mol
Synonyms	(R)-1-Amino-2,2-difluoro-1-phenylethylphosphonic Acid; (R)-2-Amino-1,1-difluoro-2-phenylethane-1-phosphonic Acid; (R)-α-Amino-α,α-difluorobenzylphosphonic Acid; (R)-ADFPPA; (R)-1,1-Difluoro-2-amino-2-phenylethylphosphonate; (R)-2-Amino-1,1-difluoro-2-phenyl-ethylphosphonic acid; (R)-Aminodifluorophenylethylphosphonic Acid
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-1,1-difluoro-2-phenylethylphosphonic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.