Description

3-(Trifluoromethyl)Thiophene-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters because the trifluoromethyl group imparts unique electronic and metabolic properties, making it a critical intermediate for developing novel active ingredients. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research sectors for creating new molecules with enhanced stability and bioactivity. Our supply ensures consistent high purity and reliable availability for your R&D and scale-up projects.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the CF3-thiophene moiety contributes to improved lipophilicity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized monomers and ligands in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile building block for designing chemical probes, enzyme inhibitors, and labeled compounds in drug discovery.
• Custom Synthesis & Contract Manufacturing: An ideal starting material for custom synthesis services requiring the introduction of a fluorinated thiophene carboxylic acid functionality.

Basic Information

Product Name	3-(Trifluoromethyl)Thiophene-2-Carboxylic Acid
CAS No.	767337-59-7
Molecular Formula	C6H3F3O2S
Molecular Weight	196.15 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-(trifluoromethyl)-; 3-(Trifluoromethyl)-2-thiophenecarboxylic acid; α-Toluenethiol, o-(trifluoromethyl)-, ω-carboxy-; 3-Trifluoromethylthiophene-2-carboxylic acid; 3-Carboxy-2-(trifluoromethyl)thiophene; 2-Carboxy-3-(trifluoromethyl)thiophene; 3-(Trifluoromethyl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)Thiophene-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.