Description

1H-Indole-1-Carboxylic Acid, 5-Bromo-2,3-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific indole-based molecular scaffold. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Protease Inhibitor Development: The bromo-substituted indole structure is valuable for creating inhibitors for various protease targets.
• Kinase Inhibitor Synthesis: Employed in the construction of heterocyclic cores found in many kinase inhibitor libraries.
• Chemical Biology Probes: Useful for synthesizing labeled or tagged molecules used to study biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 5-Bromo-2,3-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	765315-30-8
Molecular Formula	C14H14BrNO3
Molecular Weight	324.17 g/mol
Synonyms	5-Bromo-2-oxo-2,3-dihydro-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-2-oxo-2,3-dihydro-1H-indole-1-carboxylate; 5-Bromo-1-(tert-butoxycarbonyl)indolin-2-one; 5-Bromo-2-oxoindoline-1-carboxylic acid tert-butyl ester; 1-Boc-5-bromo-2-oxindole; Boc-5-bromo-oxindole; 765315-30-8
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-1-Carboxylic Acid, 5-Bromo-2,3-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request. We support development under quality systems suitable for non-GMP and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.