Description

(R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D4 is a deuterated isotopologue of a nicotinamide derivative, serving as a crucial analytical standard and research chemical. This compound matters for its role in enabling precise quantification and metabolic pathway tracing in pharmaceutical and biochemical research using mass spectrometry. It is primarily needed by researchers and quality control laboratories in the pharmaceutical industry, particularly those developing or analyzing compounds related to nicotinamide metabolism or neuropharmacology.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the accurate quantification of its non-deuterated counterpart or related metabolites in complex biological matrices.
• Metabolic Pathway Studies: Employed in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products during drug development and quality control.
• Biochemical Research: Serves as a tool compound in enzymatic assays and studies involving nicotinamide-containing cofactors or related biochemical pathways.
• Method Development and Validation: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., ICH, FDA).

Basic Information

Product Name	(R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D4
CAS No.	764661-22-5
Molecular Formula	C11H9D4N2O2
Molecular Weight	205.24 g/mol
Synonyms	1-Methyl-3-(pyridine-3-carbonyl)pyrrolidin-2-one-d4; 3-(1-Methyl-2-oxopyrrolidin-3-yl)carbonylpyridine-d4; Nicotinoylpyrrolidone Derivative-d4; Deuterated 1-Methyl-3-nicotinoylpyrrolidone; (Rac)-1-Methyl-3-nicotinoylpyrrolidone-d4
EINECS	Contact for details

Quality Control

Our (R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D4 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, essential for reliable analytical results. Each batch is characterized by advanced spectroscopic techniques, including NMR and mass spectrometry, to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which could affect stability and analytical performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.