Description

2-tert-Butyldimethylsilyloxyethanol-D4 is a deuterated derivative of a key silyl-protected alcohol building block. This compound matters for its role in advanced organic synthesis, particularly in the preparation of isotopically labeled compounds for research and development. It is primarily needed by pharmaceutical and agrochemical R&D laboratories, as well as academic institutions, for applications in mechanistic studies, metabolic pathway tracing, and the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated API Synthesis: A crucial protected intermediate for introducing deuterium atoms into target molecules to modify pharmacokinetic properties.
• Metabolic Pathway Tracing: Used in the preparation of isotopically labeled probes for studying drug metabolism and biochemical pathways using mass spectrometry.
• Mechanistic Studies: Serves as a tool compound in reaction mechanism elucidation and kinetic isotope effect (KIE) studies.
• Advanced Material Research: Potential building block for synthesizing deuterated polymers or liquid crystals for specialized analytical and electronic applications.
• Standards for Analytical Chemistry: Can be used in the development of internal standards for quantitative LC-MS/MS analysis in bioanalytical laboratories.

Basic Information

Product Name	2-tert-Butyldimethylsilyloxyethanol-D4
CAS No.	764650-43-3
Molecular Formula	C8H16D4O2Si
Molecular Weight	176.34 g/mol
Synonyms	2-[(tert-Butyldimethylsilyl)oxy]ethanol-1,1,2,2-d4; 2-(tert-Butyldimethylsiloxy)ethanol-d4; 2-Hydroxyethyl tert-butyldimethylsilyl ether-d4; Ethylene glycol monoterf-butyldimethylsilyl ether-d4; TBDMS-O-CH2CH2OH-d4; 2-TBDMS-oxyethanol-d4; 2-(TBDMSO)ethanol-d4; Deuterated TBDMS-protected ethylene glycol
EINECS	Contact for details

Quality Control

Our 2-tert-Butyldimethylsilyloxyethanol-D4 is produced under strict quality management protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D-atom %), and impurity profile. We adhere to cGMP principles for advanced intermediates, ensuring traceability and consistency for our global clientele in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.