Description

2-Cyclopropyl-4-Iodo-1H-Imidazole is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of the reactive iodo substituent and the strained cyclopropyl ring, enabling diverse functionalization and ring-opening reactions. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific heterocyclic scaffolds.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis or for creating specialty polymers with unique electronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form new carbon-carbon bonds.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships by introducing the cyclopropyl moiety into lead compounds to modulate metabolic stability and binding affinity.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and target identification.

Basic Information

Product Name	2-Cyclopropyl-4-Iodo-1H-Imidazole
CAS No.	761426-65-7
Molecular Formula	C6H7IN2
Molecular Weight	234.04 g/mol
Synonyms	4-Iodo-2-cyclopropyl-1H-imidazole; 2-Cyclopropyl-4-iodoimidazole; 1H-Imidazole, 2-cyclopropyl-4-iodo-; 4-Iodo-2-cyclopropylimidazole; 761426-65-7; 2-Cyclopropyl-4-iodo-1H-imidazole; 4-Iodo-2-cyclopropyl-1H-imidazole; 2-Cyclopropyl-4-iodoimidazole
EINECS	Contact for details

Quality Control

Every batch of 2-Cyclopropyl-4-Iodo-1H-Imidazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by 1H NMR and IR), and levels of any specified impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.