Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to facilitate complex molecular construction, offering a reactive bromo site and a robust SEM-protecting group for nitrogen. It is a critical intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its fused pyrrolopyridine core.
• Material Science: Serves as a precursor for organic electronic materials, including charge-transport layers and light-emitting components.
• Academic & Contract Research: Enables method development and exploration of new chemical space in heterocyclic and medicinal chemistry.
• Process Chemistry & Scale-up: Provides a reliable, high-purity starting material for optimizing synthetic routes from lab to pilot plant scale.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	757978-23-7
Molecular Formula	C13H19BrN2OSi
Molecular Weight	343.30 g/mol
Synonyms	5-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-SEM-7-azaindole; 5-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-7-azaindole; 5-Bromo-1-SEM-pyrrolo[2,3-b]pyridine; 5-Br-1-SEM-7AI; 5-Bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-(2-trimethylsilylethoxymethyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality systems are designed to meet the stringent requirements of research and development, with a focus on high-purity standards essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is sensitive to strong acids and should be kept away from such environments. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.