Description

(R)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-1,1'-Binaphthyl-2,2'-diol is a high-value, chiral binaphthyl derivative distinguished by its electron-deficient trifluoromethylated aromatic substituents. This compound is a critical ligand precursor and organocatalyst in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and development in the pharmaceutical, agrochemical, and advanced materials sectors, where precise stereochemical control is paramount.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal complexes (e.g., Ru, Rh, Pd) in hydrogenation, coupling, and cycloaddition reactions.
• Organocatalysis: Direct use as a chiral Brønsted acid catalyst for enantioselective transformations, such as Mannich and Pictet-Spengler reactions.
• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Material Science: Component in the development of chiral stationary phases for HPLC and in chiral molecular recognition systems.
• Agrochemical Synthesis: Enantioselective production of herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Fundamental research tool for developing new catalytic methodologies and exploring structure-activity relationships.

Basic Information

Product Name	(R)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-1,1'-Binaphthyl-2,2'-diol
CAS No.	756491-54-0
Molecular Formula	C40H20F12O2
Molecular Weight	760.57 g/mol
Synonyms	(R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diol; (R)-3,3'-Bis(3,5-di(trifluoromethyl)phenyl)-BINOL; (R)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-2,2'-dihydroxy-1,1'-binaphthyl; (R)-3,3'-(3,5-Bis(trifluoromethyl)phenyl)2-BINOL; (R)-DTB-BINOL; (R)-3,3'-Bis(3,5-Ditrifluoromethylphenyl)-1,1'-Bi-2-naphthol; Chiral DTB-BINOL Ligand
EINECS	Contact for details

Quality Control

Our production of (R)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-BINOL adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for catalytic performance. Each lot is characterized by HPLC, 1H/19F NMR, and chiral analysis to confirm identity, chemical purity, and enantiomeric excess (typically >99%). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider handling under an inert atmosphere (argon or nitrogen) to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.