Description

3-Thiophenecarboxylicacid,4-Aminotetrahydro-,Ethylester,1,1-Dioxide,cis-(9Ci) is a high-purity, cis-configured sulfone derivative of a tetrahydrothiophene carboxylic acid ester, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic architectures. This compound is essential for research and development chemists and process scale-up teams within the global pharmaceutical and agrochemical industries, where precise stereochemistry and functional group compatibility are paramount for creating next-generation compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its unique sulfone and amine functionalities.
• Chemical Research & Development: Serves as a versatile precursor for exploring new chemical entities and reaction pathways in medicinal chemistry.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the commercial production of complex target molecules.
• Ligand and Catalyst Development: The aminotetrahydrothiophene dioxide core can be utilized to create novel ligands for asymmetric catalysis.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or organic electronic materials due to its heterocyclic structure.

Basic Information

Product Name	3-Thiophenecarboxylicacid,4-Aminotetrahydro-,Ethylester,1,1-Dioxide,cis-(9Ci)
CAS No.	756448-64-3
Molecular Formula	C7H11NO4S
Molecular Weight	205.23 g/mol
Synonyms	Ethyl cis-4-amino-1,1-dioxo-tetrahydro-3-thiophenecarboxylate; cis-Ethyl 4-amino-1,1-dioxo-tetrahydrothiophene-3-carboxylate; 4-Aminotetrahydrothiophene-3-carboxylic acid ethyl ester 1,1-dioxide, cis-; (3R,4S)- or (3S,4R)-Ethyl 4-amino-1,1-dioxotetrahydrothiophene-3-carboxylate; cis-4-Amino-1,1-dioxotetrahydrothiophene-3-carboxylic acid ethyl ester; 756448-64-3; cis-Tetrahydrothiophene sulfone derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. While produced under ISO 9001 quality management systems, specifications can be tailored to meet specific customer requirements, including those for GMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.