Description

tert-Butyl 2-cyanoindoline-1-carboxylate is a high-value, protected indoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are pivotal in modern pharmaceutical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who are engaged in the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of indoline-based drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and insecticides that leverage the indoline pharmacophore.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds and molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and organic electronic materials due to its conjugated system.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in heterocyclic and asymmetric synthesis.
• Custom Synthesis: A starting point for the contract manufacturing of bespoke, high-complexity molecules for client-specific applications.

Basic Information

Product Name	tert-Butyl 2-Cyanoindoline-1-Carboxylate
CAS No.	753480-67-0
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	1-Boc-2-cyanoindoline; 2-Cyanoindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 2-cyano-2,3-dihydro-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 2-cyano-2,3-dihydro-, 1,1-dimethylethyl ester; Boc-2-cyanoindoline; 1-(tert-Butoxycarbonyl)-2-cyanoindoline; 2-Cyano-1-N-Boc-indoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-cyanoindoline-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.