Description

2-Chloro-10-[3-[4-(Trideuteriomethyl)Piperazin-1-Yl]Propyl]Phenothiazine is a deuterated derivative of a phenothiazine-piperazine compound, offering enhanced metabolic stability and pharmacokinetic properties for advanced research applications. This compound matters as a sophisticated building block and reference standard in the development of novel pharmaceuticals and biochemical probes. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly in neuroscience and receptor studies, as well as by analytical laboratories requiring high-purity labeled compounds for mass spectrometry and metabolic studies.

Application

• Pharmaceutical Research & Development: As a deuterated analog, it serves as a crucial intermediate in the synthesis of novel drug candidates, especially for central nervous system (CNS) targets, leveraging the deuterium isotope effect to potentially improve metabolic profiles.
• Biochemical & Receptor Studies: Used as a labeled ligand or probe in binding assays and pharmacological studies to investigate receptor interactions and signal transduction pathways with greater precision.
• Metabolic Pathway Tracing: Employed as an internal standard or tracer in mass spectrometry-based studies to elucidate drug metabolism and pharmacokinetics (DMPK) with high specificity.
• Reference Standard for Analytical Methods: Provides a certified high-purity material for the calibration of analytical instruments (HPLC, LC-MS) and the validation of testing methods in quality control laboratories.
• Isotope-Labeled Compound Synthesis: Acts as a key precursor for the synthesis of more complex, multi-labeled compounds for advanced research in medicinal chemistry and diagnostics.

Basic Information

Item	Detail
Product Name	2-Chloro-10-[3-[4-(Trideuteriomethyl)Piperazin-1-Yl]Propyl]Phenothiazine
CAS No.	753432-54-1
Molecular Formula	C20H22D3ClN3S
Molecular Weight	Contact for details
Synonyms	2-Chloro-10-[3-[4-(Trideuteriomethyl)-1-piperazinyl]propyl]phenothiazine; Deuterated Trifluoperazine Derivative; N-Trideuteriomethylpiperazine Phenothiazine Derivative; 2-Chloro-10-(3-(4-(methyl-d3)-1-piperazinyl)propyl)phenothiazine; CD3-Labeled Phenothiazine-Piperazine Compound; CAS 753432-54-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-10-[3-[4-(Trideuteriomethyl)Piperazin-1-Yl]Propyl]Phenothiazine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation and deuterium incorporation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.