Description

1,2-Dihydro-5-Methoxy-2-Oxo-Spiro[3H-Indole-3,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indole-piperidine structure. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Integral in the process development and scale-up synthesis of potential new chemical entities (NCEs) for preclinical and clinical trials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational drugs.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1,2-Dihydro-5-Methoxy-2-Oxo-Spiro[3H-Indole-3,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	752234-64-3
Molecular Formula	C19H24N2O4
Molecular Weight	344.41 g/mol
Synonyms	tert-Butyl 5-methoxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate; 1'-Boc-5-methoxyspiro[indoline-3,4'-piperidin]-2-one; 5-Methoxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indoline-3,4'-piperidine]-2-one, 1'-(1,1-dimethylethyl) 5-methoxy-1,2-dihydro- ester; 1,1-Dimethylethyl 1,2-dihydro-5-methoxy-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate; 1'-Boc-5-methoxyspiro[indoline-3,4'-piperidin]-2-one; 5-Methoxy-1'-Boc-spiro[indoline-3,4'-piperidin]-2-one
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting specifications for pharmaceutical R&D use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development projects requiring compliance with ICH guidelines and can provide material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.