Description

tert-Butyl 1,3-Dioxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced biological profiles. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Synthesis: Serves as a core scaffold for constructing molecules that inhibit specific protease enzymes, a common target in antiviral and anticancer therapies.
• Chemical Biology & Proteomics: Used as a specialized reagent for labeling or modifying biomolecules to study protein function and interaction.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening against biological targets.
• Advanced Organic Synthesis: Acts as a versatile starting material for academic and industrial research focused on novel spirocyclic and diazaspiro compound chemistry.

Basic Information

Product Name	tert-Butyl 1,3-Dioxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate
CAS No.	752234-60-9
Molecular Formula	C13H20N2O4
Molecular Weight	268.31 g/mol
Synonyms	8-Boc-2,8-diazaspiro[4.5]decane-1,3-dione; tert-Butyl 1,3-dioxo-2,8-diazaspiro[4.5]decane-8-carboxylate; 2,8-Diazaspiro[4.5]decane-1,3-dione, 8-(1,1-dimethylethyl) ester; 8-(tert-Butoxycarbonyl)-2,8-diazaspiro[4.5]decane-1,3-dione; Boc-DADOO; 8-Boc-2,8-diaza-spiro[4.5]decane-1,3-dione
EINECS	Contact for details

Quality Control

Our tert-Butyl 1,3-Dioxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.