Description

5-Bromo-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is a high-purity, functionalized isoquinoline derivative that serves as a critical synthetic intermediate. Its value lies in providing a versatile brominated scaffold for constructing complex molecules in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used in structure-activity relationship (SAR) studies and library synthesis due to its bromine handle for further functionalization via cross-coupling reactions.
• Agrochemical Research: Intermediate in the development of new active ingredients for crop protection products.
• Ligand and Catalyst Synthesis: Precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Academic Research: Serves as a starting material in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid
CAS No.	750549-39-4
Molecular Formula	C₁₀H₁₀BrNO₂
Molecular Weight	256.10 g/mol
Synonyms	5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 3-Isoquinolinecarboxylic acid, 5-bromo-1,2,3,4-tetrahydro-; 5-Bromo-THIQ-3-carboxylic acid; 5-Br-THIQ-3-COOH; 5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate; 750549-39-4; 5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.