Description

Hs-Peg4-Ch2Ch2Cooh CAS NO 749247-06-1 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a thiol-reactive group and a carboxylic acid terminus. This compound is a critical building block for creating stable, hydrophilic, and biocompatible crosslinks in advanced bioconjugation and materials science. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and nanotechnology sectors who require precise and reliable linker molecules for modifying proteins, peptides, surfaces, and nanoparticles.

Application

• Bioconjugation and Protein Modification: Used as a heterobifunctional crosslinker for attaching thiol-containing biomolecules (e.g., antibodies, peptides) to carboxyl-reactive surfaces or other molecules.
• PEGylation Reagent: Serves as a key intermediate in the synthesis of PEGylated therapeutics, enhancing solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: Enables the creation of hydrophilic, non-fouling coatings on nanoparticles, quantum dots, and biosensor surfaces to improve biocompatibility and targeting.
• Hydrogel Formation: Acts as a crosslinking agent in the development of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Diagnostic Assay Development: Utilized to conjugate detection molecules (enzymes, fluorophores) to solid supports or other proteins in ELISA and lateral flow assays.
• ADC (Antibody-Drug Conjugate) Linker Synthesis: A valuable precursor in the design of cleavable or non-cleavable linkers for targeted cancer therapies.
• Materials Science Research: Employed to introduce functional groups onto polymers and nanomaterials, tailoring their chemical and physical properties.

Basic Information

Product Name	Hs-Peg4-Ch2Ch2Cooh CAS NO 749247-06-1
CAS No.	749247-06-1
Molecular Formula	C15H29NO8S
Molecular Weight	383.46 g/mol
Synonyms	HS-PEG4-COOH; Thiol-PEG4-acid; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-mercapto-; 13-Mercapto-2,5,8,11-tetraoxatetradecan-14-oic acid; α-Thiol-ω-carboxy tetraethylene glycol; SH-PEG4-CH2CH2COOH; Heterobifunctional PEG, HS-PEG4-AA; PEG-based crosslinker, thiol and carboxyl
EINECS	Contact for details

Quality Control

Our Hs-Peg4-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store the product at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and minimize moisture absorption. Allow the vial to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 90.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.