Description

1H-Indole-2-Carboxylicacid,2,3-Dihydro-5-Methoxy-,(S)-(9Ci) is a high-purity, chiral indole derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of novel, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed as a chiral synthon in catalytic asymmetric reactions to introduce stereochemical complexity into target molecules.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies, given the indole core's prevalence in many natural products and receptor ligands.
• Fine Chemical Synthesis: Utilized in the custom synthesis of specialty chemicals, agrochemicals, and other complex organic molecules requiring a defined stereocenter.

Basic Information

Product Name	1H-Indole-2-Carboxylicacid,2,3-Dihydro-5-Methoxy-,(S)-(9Ci)
CAS No.	748090-00-8
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(S)-5-Methoxy-2,3-dihydro-1H-indole-2-carboxylic acid; (2S)-5-Methoxy-2,3-dihydro-1H-indole-2-carboxylic acid; 5-Methoxyindoline-2-carboxylic acid, (S)-; L-5-Methoxyindoline-2-carboxylic acid; (S)-5-Methoxyindoline-2-carboxylic acid; 748090-00-8; (S)-5-Methoxy-2,3-dihydroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carboxylicacid,2,3-Dihydro-5-Methoxy-,(S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.