Description

1,6,7,8-Indolizinetetrol, Octahydro-1,7-Dimethyl-, [1S-(1Alpha,6Ba,7Alpha,8Ba,8Aba)]- (9Ci) CAS NO 746585-37-5 is a complex, stereochemically defined indolizine derivative, a class of compounds known for their diverse biological activity and utility as advanced synthetic intermediates. This high-purity compound is critical for research and development in pharmaceutical chemistry, where precise stereochemistry is essential for biological function. It serves as a valuable building block for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, polyfunctional indolizine core.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for potential APIs, requiring high chemical and stereochemical purity.
• Biochemical Research: Potential use as a tool compound or precursor in studying enzyme inhibition or other biological mechanisms.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of other complex, high-value specialty chemicals and natural product analogs.

Basic Information

Product Name	1,6,7,8-Indolizinetetrol, Octahydro-1,7-Dimethyl-, [1S-(1Alpha,6Ba,7Alpha,8Ba,8Aba)]- (9Ci)
CAS No.	746585-37-5
Molecular Formula	C10H18O4
Molecular Weight	202.25 g/mol
Synonyms	(1S,6bR,7S,8R,8aR)-1,7-Dimethyloctahydro-1H,6H-indolizine-1,6,7,8-tetrol; Octahydro-1,7-dimethyl-1,6,7,8-indolizinetetrol, [1S-(1α,6bα,7α,8β,8aβ)]-; 1,6,7,8-Indolizinetetrol, octahydro-1,7-dimethyl-, (1S,6bR,7S,8R,8aR)-; 746585-37-5; Indolizine tetrol derivative; Chiral indolizine polyol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and stereochemical purity suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and chiral excess is provided with every shipment. We support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.