Description

5-Thiazolecarboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester is a high-value, protected amino acid derivative featuring a thiazole heterocycle, a versatile scaffold in medicinal chemistry. This compound is a critical pharmaceutical intermediate used in the synthesis of complex molecules, offering a strategic handle for further functionalization. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting infectious diseases or metabolic disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides where the thiazole moiety imparts specific biological activity.
• Peptidomimetics & PROTACs: Serves as a constrained amino acid analog in the design of peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Employed in the creation of molecular probes to study enzyme function or protein-protein interactions.
• Material Science Precursor: Potential precursor for specialty polymers or ligands in catalytic systems.

Basic Information

Product Name	5-Thiazolecarboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester
CAS No.	745078-03-9
Molecular Formula	C10H14N2O4S
Molecular Weight	258.29 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-1,3-thiazole-5-carboxylic acid methyl ester; Methyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate; Boc-Atz(5-COOMe)-OH; 2-(Boc-amino)thiazole-5-carboxylic acid methyl ester; 5-(Methoxycarbonyl)thiazol-2-ylcarbamic acid tert-butyl ester; tert-Butyl N-(5-methoxycarbonyl-1,3-thiazol-2-yl)carbamate; 2-Amino-5-thiazolecarboxylic acid, N-Boc, methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is analyzed via HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.