Description

tert-Butyl 4-(3-Iodo-1H-Indazol-6-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a protected amine and a halogenated indazole moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small-molecule drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable functional groups.
• API Development: Serves as a precursor in the development and scale-up of Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 4-(3-Iodo-1H-Indazol-6-Yl)Piperazine-1-Carboxylate
CAS No.	744219-44-1
Molecular Formula	C16H21IN4O2
Molecular Weight	428.27 g/mol
Synonyms	1-Boc-4-(3-iodo-1H-indazol-6-yl)piperazine; 1-(tert-Butoxycarbonyl)-4-(3-iodo-1H-indazol-6-yl)piperazine; tert-Butyl 4-(3-iodo-1H-indazol-6-yl)-1-piperazinecarboxylate; 6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-iodo-1H-indazole; BOC-4-(3-Iodo-1H-Indazol-6-Yl)Piperazine; 744219-44-1; 3-Iodo-6-(4-Boc-piperazin-1-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Iodo-1H-Indazol-6-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.