Description

tert-Butyl 4-(1H-Indazol-6-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core linked to an indazole moiety via a tert-butoxycarbonyl (Boc) protecting group. This compound matters for its critical role as a versatile building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Protecting Group Strategy: The Boc-protected piperazine group allows for selective deprotection and further functionalization under mild acidic conditions, facilitating complex multi-step syntheses.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from milligram to kilogram scale for preclinical and clinical trial material production.

Basic Information

Product Name	tert-Butyl 4-(1H-Indazol-6-Yl)Piperazine-1-Carboxylate
CAS No.	744219-43-0
Molecular Formula	C16H22N4O2
Molecular Weight	302.37 g/mol
Synonyms	1-Boc-4-(1H-indazol-6-yl)piperazine; 1-(tert-Butoxycarbonyl)-4-(1H-indazol-6-yl)piperazine; 4-(1H-Indazol-6-yl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(1H-indazol-6-yl)-1-piperazinecarboxylate; 6-(4-Boc-piperazin-1-yl)-1H-indazole; BOC-4-(1H-Indazol-6-yl)piperazine; 744219-43-0; 1-Piperazinecarboxylic acid, 4-(1H-indazol-6-yl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(1H-Indazol-6-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.