Description

1-Boc-4-(3-Iodo-1H-Indazol-4-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core functionalized with a protected amine (Boc) and a halogenated indazole moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, CNS disorders, and other therapeutic areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable halogen and protected amine sites.
• API Development: Serves as a critical building block in the development and scale-up of Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Synthesis: The iodine atom allows for further functionalization via cross-coupling reactions, useful for creating biochemical probes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client molecules.

Basic Information

Product Name	1-Boc-4-(3-Iodo-1H-Indazol-4-Yl)Piperazine
CAS No.	744219-32-7
Molecular Formula	C16H21IN4O2
Molecular Weight	428.27 g/mol
Synonyms	1-Boc-4-(3-iodo-1H-indazol-4-yl)piperazine; tert-Butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate; 4-(3-Iodo-1H-indazol-4-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-iodo-1H-indazol-4-yl)piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-(3-iodo-1H-indazol-4-yl)-; BOC-4-(3-Iodo-1H-Indazol-4-Yl)Piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(3-Iodo-1H-Indazol-4-Yl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.