Description

Batefenterol is a novel, long-acting dual-pharmacology bronchodilator designed for the treatment of chronic obstructive pulmonary disease (COD). This compound is significant for its innovative mechanism, combining muscarinic antagonist and β2-adrenergic agonist (MABA) activities in a single molecule. It is primarily needed by pharmaceutical R&D teams and manufacturers developing next-generation respiratory therapeutics to address the limitations of existing treatments.

Application

• Pharmaceutical Active Ingredient: Primary use as the key active pharmaceutical ingredient (API) in the formulation of inhalable medications for chronic respiratory diseases.
• Respiratory Disease Research: A critical reference standard and investigational compound in preclinical and clinical research focused on COPD and asthma.
• Drug Development Studies: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies to establish safety and efficacy profiles.
• Formulation Development: Serves as the core component in the development of dry powder inhalers (DPIs), metered-dose inhalers (MDIs), and nebulizer solutions.
• Mechanistic Studies: Used in biochemical assays to study the dual MABA mechanism of action and receptor binding kinetics.

Basic Information

Product Name	Batefenterol
CAS No.	743461-65-6
Molecular Formula	C26H28N4O6
Molecular Weight	492.52 g/mol
Synonyms	GSK-961081; (R)-3-[(R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-1-(2-methoxyphenethyl) pyrrolidin-2-one; Batefenterol hemisuccinate (common salt form); GSK961081; Dual-pharmacology MABA bronchodilator; 5-[(1R)-2-{[(2R)-2-Oxo-1-(2-phenylethyl)-3-pyrrolidinyl]amino}-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone
EINECS	Contact for details

Quality Control

Our Batefenterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. Keep the container sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.