Description

1H-Benzimidazole-5-Thiol, 7-Amino-2-Methyl- CAS NO 742048-19-7 is a high-purity, multi-functional benzimidazole derivative with a reactive thiol and amino group, serving as a critical advanced intermediate in pharmaceutical and specialty chemical synthesis. Its molecular structure makes it a valuable building block for creating compounds with targeted biological activity and material properties. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients or functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzymes or receptors where the benzimidazole core is pharmacologically active.
• Agrochemical Synthesis: Used in the development of new fungicides, herbicides, or plant growth regulators that leverage the benzimidazole scaffold for bioactivity.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialty polymers, ligands for metal-organic frameworks (MOFs), or advanced organic materials.
• Chemical Biology & Proteomics: The thiol group allows for site-specific conjugation or labeling of proteins and other biomolecules for research and diagnostic applications.
• Dye & Pigment Intermediate: Serves as a building block for synthesizing complex heterocyclic dyes and organic pigments.
• Catalyst Ligand Precursor: Used to synthesize specialized ligands for homogeneous catalysis in fine chemical manufacturing.

Basic Information

Item	Details
Product Name	1H-Benzimidazole-5-Thiol, 7-Amino-2-Methyl-
CAS No.	742048-19-7
Molecular Formula	C8H9N3S
Molecular Weight	179.24 g/mol
Synonyms	7-Amino-2-methyl-1H-benzimidazole-5-thiol; 2-Methyl-7-amino-5-mercaptobenzimidazole; 5-Mercapto-7-amino-2-methylbenzimidazole; 7-Amino-2-methyl-5-mercaptobenzimidazole; 1H-Benzimidazole-5-thiol, 7-amino-2-methyl-; 742048-19-7; 7-Amino-2-methylbenzimidazole-5-thiol
EINECS	Contact for details

Quality Control

Every batch of 1H-Benzimidazole-5-Thiol, 7-Amino-2-Methyl- is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider packaging under an inert gas such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to brown powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.