Description

5-[(1S)-3-(Methylamino)-1-Thiophen-2-Ylpropoxy]Naphthalen-2-Ol is a chiral, naphthol-based organic compound featuring a thiophene moiety and a methylamino side chain, making it a sophisticated intermediate for advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the research and development of novel therapeutic agents, particularly those targeting neurological and cardiovascular pathways. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to develop new drug candidates with specific stereochemical and pharmacological properties.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug research.
• Biochemical Research: Used as a reference standard or probe compound in pharmacological studies to investigate receptor binding and enzyme inhibition mechanisms.
• Process Chemistry Development: Serves as a key intermediate in scaling up synthetic routes for potential drug candidates during preclinical and process optimization stages.
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic methodologies due to its defined (S)-configuration and complex molecular architecture.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	5-[(1S)-3-(Methylamino)-1-Thiophen-2-Ylpropoxy]Naphthalen-2-Ol
CAS No.	741693-76-5
Molecular Formula	C19H21NO2S
Molecular Weight	327.44 g/mol
Synonyms	(S)-5-[3-(Methylamino)-1-(thiophen-2-yl)propoxy]naphthalen-2-ol; 5-[(1S)-3-(Methylamino)-1-(2-thienyl)propoxy]-2-naphthol; 741693-76-5; (S)-Naphthol thiophene methylamino ether; 2-Naphthol, 5-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]-; A potential intermediate for Carvedilol analogs
EINECS	Contact for details

Quality Control

Our 5-[(1S)-3-(Methylamino)-1-Thiophen-2-Ylpropoxy]Naphthalen-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.