Description

2H-Cyclopenta[B]Furan-2-One, 5-Aminohexahydro-6-Hydroxy-, (3As,5R,6R,6Ar)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique fused bicyclic structure, featuring both amino and hydroxyl functional groups, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Asymmetric Catalysis Ligand Precursor: Utilized in the synthesis of novel chiral ligands and organocatalysts due to its rigid, functionalized backbone.
• Fine Chemical Synthesis: Acts as a building block for the production of specialty chemicals, agrochemicals, and high-value flavor & fragrance compounds.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in stereoselective synthesis and natural product analog development.
• Peptidomimetic Research: Its structure is valuable for designing and synthesizing conformationally constrained peptide mimics for biochemical studies.

Basic Information

Product Name	2H-Cyclopenta[B]Furan-2-One, 5-Aminohexahydro-6-Hydroxy-, (3As,5R,6R,6Ar)- (9Ci)
CAS No.	741658-49-1
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(3aS,5R,6R,6aR)-5-Aminohexahydro-6-hydroxy-2H-cyclopenta[b]furan-2-one; 5-Aminohexahydro-6-hydroxy-2H-cyclopenta[b]furan-2-one (stereoisomer); Hexahydro-5-amino-6-hydroxy-2H-cyclopenta[b]furan-2-one; CAS 741658-49-1; Chiral amino lactone derivative; Fused bicyclic amino alcohol lactone.
EINECS	Contact for details

Quality Control

Every batch of 2H-Cyclopenta[B]Furan-2-One, 5-Aminohexahydro-6-Hydroxy-, (3As,5R,6R,6Ar)- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements of research and cGMP-starting material applications. A detailed Certificate of Analysis (COA) including chiral purity is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.