Description

tert-Butyl 1H-Indole-5-Caboxylate CAS NO 741606-16-6 is a high-purity, protected indole derivative that serves as a versatile and critical building block in advanced organic synthesis. Its value lies in providing a reactive carboxylic acid handle on the indole scaffold while offering stability and selectivity for complex molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Building block for creating novel fungicides, herbicides, and plant growth regulators with enhanced efficacy.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and advanced functional materials.
• Peptide Mimetics & Bioconjugation: The tert-butyl ester group allows for selective deprotection, making it valuable for creating indole-containing peptide analogs and bioconjugates.
• Chemical Biology Probes: Serves as a scaffold for developing fluorescent probes and activity-based protein profiling (ABPP) agents.
• Academic & R&D Laboratories: Fundamental reagent for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	tert-Butyl 1H-Indole-5-Caboxylate
CAS No.	741606-16-6
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	5-(tert-Butoxycarbonyl)indole; 1H-Indole-5-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl indole-5-carboxylate; 5-Carboxyindole tert-butyl ester; Indole-5-carboxylic acid tert-butyl ester; 5-(BOC)indole; BOC-Indole-5-COOH tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1H-Indole-5-Caboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.