Description

3-Amino-1-(5-(Hydroxymethyl)Isoindolin-2-Yl)-3-Methylbutan-1-One is a specialized organic compound featuring an isoindoline core, an amino group, and a hydroxymethyl substituent, making it a versatile chiral building block. This compound matters for its role as a key intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories focused on creating novel therapeutic agents, such as enzyme inhibitors or receptor modulators.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or oncology targets.
• Protease Inhibitor Development: Serves as a core structural element for designing and screening novel protease inhibitors due to its amino and carbonyl functionalities.
• Peptidomimetic Research: Used in constructing peptidomimetics and constrained peptide analogs to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic reactions to introduce stereogenic centers.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	3-Amino-1-(5-(Hydroxymethyl)Isoindolin-2-Yl)-3-Methylbutan-1-One
CAS No.	739365-44-7
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	3-Amino-1-(5-(hydroxymethyl)-2,3-dihydro-1H-isoindol-2-yl)-3-methylbutan-1-one; 3-Methyl-3-amino-1-(5-hydroxymethylisoindolin-2-yl)butan-1-one; 2-(3-Amino-3-methyl-1-oxobutyl)-5-(hydroxymethyl)isoindoline; (R/S)-3-Amino-1-(5-(hydroxymethyl)isoindolin-2-yl)-3-methylbutan-1-one; Amino Isoindoline Derivative CAS 739365-44-7
EINECS	Contact for details

Quality Control

Our 3-Amino-1-(5-(Hydroxymethyl)Isoindolin-2-Yl)-3-Methylbutan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.