Description

3-Amino-1-(4-Hydroxyisoindolin-2-Yl)-3-Methylbutan-1-One is a high-purity, advanced pharmaceutical intermediate with a complex isoindoline-based structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this material to develop next-generation drug candidates, leveraging its unique chemical framework to create molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Used in the research and production of small molecule inhibitors for various kinase targets due to its amine and carbonyl functionalities.
• Peptidomimetic Research: Acts as a scaffold for creating peptide-like compounds with enhanced metabolic stability and bioavailability.
• Chemical Biology & Probe Development: Employed in the creation of chemical probes to study enzyme function and biological pathways in academic and industrial research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	3-Amino-1-(4-Hydroxyisoindolin-2-Yl)-3-Methylbutan-1-One
CAS No.	739365-43-6
Molecular Formula	C₁₃H₁₈N₂O₂
Molecular Weight	234.30 g/mol
Synonyms	3-Amino-1-(4-hydroxy-2,3-dihydro-1H-isoindol-2-yl)-3-methylbutan-1-one; 3-Amino-3-methyl-1-(4-hydroxyisoindolin-2-yl)butan-1-one; 1-(4-Hydroxyisoindolin-2-yl)-3-amino-3-methylbutan-1-one; 2-(3-Amino-3-methyl-1-oxobutyl)-4-hydroxyisoindoline; 739365-43-6; Amino-methyl-hydroxyisoindolinone derivative
EINECS	Contact for details

Quality Control

Our 3-Amino-1-(4-Hydroxyisoindolin-2-Yl)-3-Methylbutan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.