Description

3-Amino-1-(4-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique isoindolinone scaffold. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary drug candidates, especially those with fluorinated heterocyclic structures.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• API Process Development: Serves as a critical synthon in scaling up and optimizing synthetic routes for new chemical entities (NCEs).
• Preclinical Studies: Employed in the production of compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for exploring new organic synthetic methodologies and bioactivity.

Basic Information

Product Name	3-Amino-1-(4-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One
CAS No.	739365-40-3
Molecular Formula	C₁₃H₁₅FN₂O
Molecular Weight	234.27 g/mol
Synonyms	3-Amino-1-(4-fluoroisoindolin-2-yl)-3-methylbutan-1-one; 3-Methyl-3-amino-1-(4-fluoroisoindolin-2-yl)butan-1-one; 1-(4-Fluoroisoindolin-2-yl)-3-amino-3-methylbutan-1-one; 739365-40-3; 4-Fluoro-2-(3-amino-3-methyl-1-oxobutyl)isoindoline; 2-(3-Amino-3-methyl-1-oxobutyl)-4-fluoroisoindoline
EINECS	Contact for details

Quality Control

Our 3-Amino-1-(4-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.