Description

2,2,2-Trifluoroethylamine Hydrochloride is a versatile organofluorine building block and a key intermediate in advanced chemical synthesis. Its value lies in the introduction of the trifluoroethylamine moiety, which is crucial for modulating the physicochemical and biological properties of target molecules. This high-purity compound is essential for research and production in the pharmaceutical, agrochemical, and specialty materials sectors, where precise fluorine incorporation is required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-cancer agents, and protease inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, stability, and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a key precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) to improve performance and durability.
• Peptide Modification & Bioconjugation: Employed to introduce fluorinated tags or labels into peptides and proteins for biochemical research, imaging, and diagnostic applications.
• Fluorinated Polymer & Resin Production: Acts as a monomer or modifier in the synthesis of specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Catalyst & Ligand Development: Utilized in the design and synthesis of novel fluorinated ligands for catalysis in asymmetric synthesis and other complex organic transformations.

Basic Information

Product Name	2,2,2-Trifluoroethylamine Hydrochloride
CAS No.	373-88-6
Molecular Formula	C2H5ClF3N
Molecular Weight	135.51 g/mol
Synonyms	2,2,2-Trifluoroethanamine Hydrochloride; 2,2,2-Trifluoroethylammonium Chloride; 1,1,1-Trifluoro-2-aminoethane Hydrochloride; Trifluoroethylamine HCl; 2-Amino-1,1,1-trifluoroethane Hydrochloride; α,α,α-Trifluoroethylamine Hydrochloride; TFE-Amine HCl; 373-88-6
EINECS	206-776-1

Quality Control

Our 2,2,2-Trifluoroethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.