Description

3-Amino-1-(5-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated isoindoline scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of specific enzymes relevant to disease pathology.
• Fluorinated Compound Library Synthesis: Essential for creating diverse chemical libraries that incorporate fluorine to modulate pharmacokinetic properties like metabolic stability and membrane permeability.
• Preclinical Drug Development: Employed in the production of compounds for in vitro and in vivo biological testing and toxicology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	3-Amino-1-(5-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One
CAS No.	739365-36-7
Molecular Formula	C₁₃H₁₇FN₂O
Molecular Weight	236.29 g/mol
Synonyms	3-Amino-1-(5-fluoroisoindolin-2-yl)-3-methylbutan-1-one; 3-Methyl-3-amino-1-(5-fluoroisoindolin-2-yl)butan-1-one; 739365-36-7; 5-Fluoro-2-(3-amino-3-methyl-1-oxobutyl)isoindoline; 1-(5-Fluoroisoindolin-2-yl)-3-amino-3-methylbutan-1-one; 3-Amino-3-methyl-1-(5-fluoroisoindolin-2-yl)butan-1-one
EINECS	Contact for details

Quality Control

Our production of 3-Amino-1-(5-Fluoroisoindolin-2-Yl)-3-Methylbutan-1-One adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements or regulatory standards for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.