Description

1-(Pivaloyloxymethyl)-1H-Indole-3-Carboxylic Acid CAS NO 739365-21-0 is a high-purity, advanced pharmaceutical intermediate belonging to the indole carboxylic acid derivative class. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its unique structure enables precise molecular modifications. It is essential for research and development chemists and production facilities in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for innovative drug discovery and manufacturing processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and neurology research.
• API Synthesis: Used as a protected carboxylic acid moiety in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Prodrug Development: The pivaloyloxymethyl (POM) ester group makes it valuable for designing prodrugs to enhance bioavailability and pharmacokinetic properties.
• Bioconjugation & Labeling: Serves as a versatile linker or building block for bioconjugation chemistry in diagnostic and therapeutic agent development.
• Chemical Research: Employed in academic and industrial R&D for exploring new heterocyclic chemistry and creating specialized compound libraries.
• Fine Chemical Production: Integral to the manufacture of high-value specialty chemicals and advanced materials.

Basic Information

Item	Details
Product Name	1-(Pivaloyloxymethyl)-1H-Indole-3-Carboxylic Acid
CAS No.	739365-21-0
Molecular Formula	C15H17NO4
Molecular Weight	275.30 g/mol
Synonyms	1-[(2,2-Dimethylpropanoyloxy)methyl]-1H-indole-3-carboxylic acid; POM-Indole-3-carboxylic Acid; 1H-Indole-3-carboxylic acid, 1-[(2,2-dimethyl-1-oxopropoxy)methyl]-; 1-(Pivaloyloxymethyl)indole-3-carboxylic acid; tert-Butylcarbonyloxymethyl indole-3-carboxylate; Indole-3-carboxylic acid POM ester; 739365-21-0; POM-Ica
EINECS	Contact for details

Quality Control

Our 1-(Pivaloyloxymethyl)-1H-Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.