Description

1-Neopentyl-1H-Indole-5-Carboxylic Acid CAS NO 739365-11-8 is a high-purity, synthetically derived indole derivative featuring a neopentyl group at the 1-position, which confers enhanced steric bulk and metabolic stability. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of targeted therapeutics, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• Chemical Biology Probes: Used to develop selective probes for studying enzyme function and protein-protein interactions in biological systems.
• Agrochemical Development: Potential intermediate in the research and synthesis of novel crop protection agents and herbicides.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	1-Neopentyl-1H-Indole-5-Carboxylic Acid
CAS No.	739365-11-8
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	1-Neopentyl-1H-indole-5-carboxylic acid; 5-Carboxy-1-neopentylindole; 1-(2,2-Dimethylpropyl)-1H-indole-5-carboxylic acid; 1-tert-Butylmethyl-1H-indole-5-carboxylic acid; Indole-5-carboxylic acid, 1-neopentyl-; 739365-11-8; 1-Neopentylindole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Neopentyl-1H-Indole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.