Description

6,7-Dimethoxy-3,4-1H-Isoquinoline-1-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific isoquinoline scaffold. This compound is of significant commercial importance as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its functionalized isoquinoline core.
• Research & Development (R&D): Employed in academic and industrial laboratories for the development of new synthetic methodologies and novel chemical entities.
• Agrochemical Synthesis: Potential application as an intermediate in the development of advanced crop protection agents with specific biological activity.
• Material Science Research: Investigated for the synthesis of specialized organic ligands or functional molecules for advanced materials.

Basic Information

Product Name	6,7-Dimethoxy-3,4-1H-Isoquinoline-1-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	738629-59-9
Molecular Formula	C₁₇H₂₁NO₆
Molecular Weight	335.35 g/mol
Synonyms	2-tert-Butyl 6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate; 1,2-Dicarboxylic Acid, 3,4-Dihydro-6,7-dimethoxy-1H-isoquinoline-, 2-(1,1-Dimethylethyl) Ester; 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic Acid 2-tert-Butyl Ester; tert-Butyl 6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate-1-carboxylate (tautomeric form); BOC-Protected Isoquinoline Derivative; 738629-59-9 (CAS Registry)
EINECS	Contact for details

Quality Control

Our production of 6,7-Dimethoxy-3,4-1H-Isoquinoline-1-Dicarboxylic Acid 2-tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.