Description

Bicyclo[2.1.1]Hexan-1-Amine Hydrochloride is a high-purity, synthetically derived amine salt characterized by its unique strained bicyclic framework. This compound is a critical building block in advanced pharmaceutical research and fine chemical synthesis, valued for its rigid, three-dimensional structure that can impart desirable properties to target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor or scaffold in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Agrochemical Research: Used in developing new generation herbicides and pesticides, where its bicyclic structure can enhance biological activity and environmental profile.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis, including asymmetric hydrogenation and cross-coupling reactions.
• Material Science Monomer: Acts as a functional monomer for creating polymers with unique thermal and mechanical properties due to its rigid backbone.
• Peptidomimetics: Incorporated into peptide analogs to confer conformational restraint, improving metabolic stability and receptor selectivity.
• Chemical Biology Probes: Utilized as a core structure in designing molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Bicyclo[2.1.1]Hexan-1-Amine Hydrochloride
CAS No.	732944-06-8
Molecular Formula	C6H12ClN
Molecular Weight	133.62 g/mol
Synonyms	1-Aminobicyclo[2.1.1]hexane hydrochloride; Bicyclo[2.1.1]hexan-1-amine, hydrochloride; 1-Bicyclo[2.1.1]hexanylammonium chloride; (1R,4S)-Bicyclo[2.1.1]hexan-1-amine hydrochloride (for enantiopure form); endo-Bicyclo[2.1.1]hexan-1-amine hydrochloride; 2,5-Dihydro-1H-bicyclo[2.1.1]hexan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[2.1.1]Hexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis where applicable, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.