Description

3(2H)-Indolizinone,Hexahydro-5,7-Dimethyl-,(5R,7S,8Ar)-(9Ci) is a high-purity, stereochemically defined heterocyclic compound with the CAS number 727985-47-9. This advanced pharmaceutical intermediate is valued for its precise molecular architecture, which is critical for synthesizing complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of target molecules.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis due to its defined (5R,7S,8Ar) configuration.
• Chemical Biology Probes: Acts as a core structure for developing molecular probes to study biological pathways and target validation.

Basic Information

Product Name	3(2H)-Indolizinone,Hexahydro-5,7-Dimethyl-,(5R,7S,8Ar)-(9Ci)
CAS No.	727985-47-9
Molecular Formula	C10H17NO
Molecular Weight	167.25 g/mol
Synonyms	Hexahydro-5,7-dimethyl-3(2H)-indolizinone, (5R,7S,8aR)-; (5R,7S,8aR)-Hexahydro-5,7-dimethyl-3(2H)-indolizinone; (5R,7S,8aR)-5,7-Dimethyloctahydroindolizin-3-one; 727985-47-9; 3(2H)-Indolizinone, hexahydro-5,7-dimethyl-, (5R,7S,8aR)-; (8aR,5R,7S)-Hexahydro-5,7-dimethyl-3(2H)-indolizinone
EINECS	Contact for details

Quality Control

Our 3(2H)-Indolizinone,Hexahydro-5,7-Dimethyl-,(5R,7S,8Ar)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.