Description

5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid is a high-purity, multi-functional indole derivative serving as a critical advanced pharmaceutical intermediate. Its molecular structure, featuring reactive formyl and carboxylic acid groups on a fluorinated indole scaffold, makes it an indispensable building block for the synthesis of complex bioactive molecules. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent, fluorinated drug candidates targeting various disease pathways.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) and create novel chemical libraries.
• API Synthesis: Used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), where the fluorine atom and indole core are crucial for metabolic stability and target binding.
• Bioconjugation & Probe Development: The formyl group allows for site-specific bioconjugation, useful in creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Agrochemical Research: Employed in the development of new-generation fluorinated agrochemicals with enhanced efficacy and environmental profiles.
• Material Science: Investigated as a monomer or building block for specialty polymers and organic electronic materials due to its conjugated system.

Basic Information

Item	Detail
Product Name	5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid
CAS No.	726206-78-6
Molecular Formula	C10H6FNO3
Molecular Weight	207.16 g/mol
Synonyms	5-Fluoro-3-formyl-1H-indole-2-carboxylic acid; 2-Carboxy-5-fluoro-1H-indole-3-carboxaldehyde; 5-Fluoro-1H-indole-2,3-dicarboxaldehyde-2-carboxylic acid; 5-Fluoro-3-formylindole-2-carboxylic acid; 726206-78-6; 5-Fluoroindole-2,3-dicarboxaldehyde-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 5-fluoro-3-formyl-
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to moisture and light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.