Description

(1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazol-4-Yl)Boronic Acid is a sophisticated organoboron building block featuring a pyrazole core protected by a SEM (2-(trimethylsilyl)ethoxymethyl) group. This compound is critical for enabling complex synthetic transformations in advanced chemical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular architectures via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for synthesizing biaryl and heteroaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs) and candidate molecules, particularly those containing functionalized pyrazole moieties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	(1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazol-4-Yl)Boronic Acid
CAS No.	719296-53-4
Molecular Formula	C10H21BN2O3Si
Molecular Weight	256.19 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-boronic acid; 1-[[2-(Trimethylsilyl)ethoxy]methyl]-1H-pyrazole-4-boronic acid; 1H-Pyrazole-4-boronic acid, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; (1-SEM-1H-pyrazol-4-yl)boronic acid; SEM-Pyrazole-4-Boronic Acid; 4-Borono-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our (1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazol-4-Yl)Boronic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is analyzed using advanced techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
NMR Analysis	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.